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Metabolic Psychiatry

We fund research with the promise of transforming and saving lives, and partner with our grantees to support  translational and clinical studies that address one or more of the following topics:
  • Quantitative or qualitative approaches to understanding the use of metabolic therapies in serious mental illness.
  • Mechanisms of action and predictive biomarkers in using metabolic therapies for serious mental illness.
  • Clinical research investigating the fundamental link between metabolic function and psychiatric illness.
  • Building metabolic approaches into clinical practice, with an emphasis on embedding research into care.
In addition to funding research, we also invest in building capacity across research and clinical fields. Current efforts include creating continuing medical education for medical professionals, supporting funded investigators’ communication capacities, and convening researchers to create consensus treatment guidelines focused on ketogenic therapies.

More than a dozen clinical trials of ketogenic therapy for serious mental illness are now completed or underway for conditions that include major depression, schizophrenia spectrum disorder, bipolar disorder, and anorexia.

Additional trials not listed here are in process for many other brain-based disorders, including anxiety, Alzheimer’s disease, ADHD, autism, post-traumatic stress disorder, and alcohol use disorder.

Highlighted grants

We invest in mechanistic clinical trials and innovative science focused on adapting evidence-based metabolic interventions to bipolar disorder, schizophrenia spectrum disorders, major depression and anorexia nervosa.

Chiye Aoki, PhD New York University Investigate the ameliorative properties of ketogenic diet upon anorexia nervosa using the activity-based anorexia (ABA) mouse model Read more
Harry Campbell, MD, Iain Campbell, PhD & Daniel Smith, MD University of Edinburgh Phase 2 Clinical Trial and Mechanistic Study of Ketogenic Diet in Bipolar Disorder Read more
Virginie-Anne Chouinard, MD & Dost Ongur, MD, PhD McLean Hospital A randomized controlled clinical trial of the ketogenic diet for brain energy metabolism and psychiatric symptoms in first episode bipolar disorder Read more
Dominic D’Agostino, PhD University of South Florida Improving Cognitive-Behavioral and Cardio-Metabolic Health with Continuous Glucose Monitoring Read more
Elizabeth Errico Children’s Mental Health Resource Center Ketogenic Therapy in Action: A Pilot Program to Collect Case Study Data on the Use of the Ketogenic Diet to Treat Bipolar Disorder in Children Ages 8-17 Read more
Scott Fears, MD Amae Health Implementation and Study of Ketogenic Therapy in Outpatient Members with Serious Mental Illness
Judith Ford, PhD University of California, San Francisco Can Neural Network Instability in Schizophrenia be Improved with a Very Low Carbohydrate Ketogenic Diet? Read more
Guido Frank, MD University of California, San Diego Therapeutic Ketogenic Diet in Anorexia Nervosa: Therapeutic Ketogenic Diet to Treat Anorexia Nervosa-Specific Cognitions and Behaviors Read more
Mark Frye, MD, Kyla Lara-Breitinger, MD & Francisco Lopez-Jimenez, MD Mayo Clinic 16-Week Ketogenic Intervention for Bipolar Depression: Roadmap Clinical Trial Driving Clinical Implementation Read more
Ally Houston, PhD Candidate Oxford University 16-Week Study of Keto in ADHD with Depression with Coaching and MetPsy App
David Miklowitz, PhD & Child and Adolescent Bipolar Network University of California, Los Angeles A Ketogenic Diet Approach to Bipolar Disorder in Adolescents Read more
Lilianne Mujica-Parodi, PhD Stony Brook University Use of ketosis in modulating metabolic pathways in bipolar disorder Read more
Mary Phillips, MD University of Pittsburgh Examining Neurobiological Mechanisms Underlying the Therapeutic Effect of the Ketogenic Diet in Bipolar Disorder Read more
Zoltan Sarnyai, PhD & Carlo Longhitano, MD James Cook University, Australia Pilot Trial of Ketogenic Diet in Bipolar Disorder and Schizophrenia Read more
Shebani Sethi, MD Stanford University Impact of a Ketogenic Diet on Metabolic and Psychiatric Health in Patients With Schizophrenia or Bipolar Illness Read more
Jeff Volek, PhD, RD The Ohio State University Ketogenic Intervention in Depression (KIND) Study in a college population Read more
Metabolic Psychiatry Meeting 2024

METABOLIC PSYCHIATRY RETREATS

Baszucki Group’s annual Metabolic Psychiatry retreats convene researchers, clinicians, entrepreneurs, funders, and those with lived experience in metabolic psychiatry. Now in its third year, the collaborative, discussion-based sessions focus on brainstorming what it will take to change clinical practice and make metabolic therapies, particularly therapeutic carbohydrate restriction, mainstream care for mental illnesses.

Metabolic Psychiatry Meeting 2023
Metabolic Psychiatry Meeting 2022

2022 RETREAT WELCOME REMARKS

Hear David Baszucki and Jan Ellison Baszucki share their family’s story at the first Metabolic Psychiatry Roadmap Retreat.

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